6-硫-6-烷硫基-12H-氯溴代双苯并d,g1,3,2-二氧磷杂八环的合成

Synthesis of 6-Alkylthio-12H-Bromo and Chloro Substituted Dibenzo-d,g1,3,2-Dioxaphosphocin-6-Sulfides

摘要: 通过双 2 -羟基 - 3-溴 (氯 ) - 5-氯 (溴 )代苯基甲烷 4 A(4 B)与 P4 S10在三乙胺存在下关环 ,得到中间体 6 -硫 -巯基 - 4 ,8-二溴 (氯 ) - 2 ,10 -二氯 (溴 ) - 12 H -双苯并 d,g 1,3,2 -二氧磷杂八环三乙胺盐 5A(5B)。后者与卤代物反应得到了一系列相应的酯 6。测试并讨论了合成的 6的 1H、31P、13 C NMR、MS及抑菌活性。

Abstract: The synthesis of new 4,8 dibromo(chloro) 2,10 dichloro(bromo) 6 alkylthio 12 H dibenzo d,g1,3,2 dioxaphosphocin 6 sulfides 6 was achieved in two steps with high yields from bis 2 hydroxy 3 bromo(chloro) 5 chloro(bromo)phenylmethane 4A(4B),triethyl amine and P 4S 10 which produced the key intermediate 4,8 dibromo(chloro) 2,10 dichloro(bromo) 6 mercaptao 12 H dibenzo d,g1,3,2 dioxaphosphocin 6 sulfide triethyl amine salt 5A(5B). Treatment of 5A(5B)with alkylhalides and KI led members of 6A(6B). 31P、 1H、 13 C NMR and MS of 6 were evaluated and discussed.The fungistatic activity of 6 were described.