Abstract: The results showed that it was effective for bioremediation of metsulfuron-methyl to add Penicillium sp.or compost to contaminated soil. The degradation rate of metsulfuron-methyl was significantly improved after addition of selected Penicillium sp.or compost to soil, and the half-lives were sharply decreased from 162.3 days to 42.5~51.6 days. At 56 days after treatment, the bound residues of metsulfuron-methyl were only 1.1%~4.6% in Penicillium sp.or compost treated soils, but were 35.6% in control sample.