N-(5-芳基-1,3,4-嗯二唑-2-基)-N'-α-萘乙酰基硫脲的合成及杀菌活性

Synthesis and Fungicidal Activity of N-5-Aryl-1,3,4-thiadiazol-2-yl-N'-α-Naphthylacetylthioureas (Department of Chemistry, Central China Normal University, Wuhan 430079, China)

摘要: 从α-萘乙酸出发,合成酰基异硫氰酸酯,然后与2-氨基-5-芳基-1,3,4-嗯二唑反应合成了8个新的酰基硫脲类化合物 Ⅱa~Ⅱh 。所有化合物的结构均经元素分析、红外光谱、核磁共振氢谱和质谱确认。同时对6种病原菌进行了生物活性测试,结果发现,在50 mg/L下,所有目标化合物对黄瓜灰霉病菌Botrytis cinereapers的抑制效果较好,除 Ⅱa 外,其他化合物抑制率都达到80%以上。

Abstract: A series of novel N-(5-aryl-1,3,4-oxadiazol-2-yl)-N'-α-naphthylacetylthioureas were synthesized from 2-amino-5-aryl-1,3,4-oxadiazoles. Their structures had been confirmed by IR, MS,1H NMR and elemental analysis. The results of biological test showed that most of these compounds had good fungicidal activity. The fungicidal activity to Botrytis cinereapers, could mostly reach 80%.