含1,2,4-三唑基和肟醚基的N-甲氧基氨基甲酸酯类化合物的合成及杀菌活性

HT Synthesis and Fungicidal Activity of N-Methoxylcarbamates Containing 1,2,4-Triazole and Oxime Ether

摘要: 通过(Z)-1-(取代苯基)-2-(1H-1,2,4-三唑-1-基)乙酮肟与N-甲氧基-N-(2-溴甲基苯基)氨基甲酸甲酯反应,合成了11个新的含有三唑基和肟醚基的N-甲氧基氨基甲酸酯类化合物( V1 ~ V11 ),其结构均经1H NMR、IR、LC/MS及元素分析确证。对合成的化合物进行了离体抑菌活性实验,结果表明:在50 mg/L下,所有化合物对小麦赤霉病菌Gibberella zeae (Schw.)Petch、稻瘟病菌Pyricularia oryzae Cav.和黄瓜灰霉病菌Botrytis cinerea Pers.都有一定的抑菌活性,其中 V4 、 V11 对稻瘟病菌的抑菌活性分别达96.5%和96.7%,对黄瓜灰霉病菌的抑菌活性分别达到95.9%和90%。

Abstract: Eleven novel N-methoxylcarbamates containing 1,2,4-triazole and oxime ether group were synthesized from (Z)-1-substituted phenyl-2-(1H-1,2,4-triazol-1-yl)-ethanoxime and methyl N-methoxy-N-(2-bromomethylphenyl) carbamates. All compounds were confirmed by 1H NMR, IR, LC/MS and elemental analysis. The results of preliminary fungicidal tests in vitro showed that some compounds prossessed fungicidal activities inhibiting Gibberella zeae, Pyricularia oryzae and Botrytis cinerea at the concentration of 50 mg/L. The inhibitory ratio of V4 and V11 against P. oryzae were 96.5% and 96.7%, the ratio against B. cinerea were 95.9% and 90%.