Abstract: Using fluorine-containing compounds as starting material, 28 novel 6-fluoro-2- pyrimindinyloxy-N-substituted phenyl benzylamine derivatives were synthesized by two different routes, which are imination, deoxidation, pyrimidinyloxylation and pyrimidinyloxylation, bromination and amination. Preliminary bioassay indicates that 12 compounds showed excellent herbicidal activities, the inhibition rate of most compounds was above 80% at 75 g a.i./hm2 against both pre- and post-emergence of Echinochloa crusgalli, Amaranthus retroflexus, etc.