N-酰基苯并噁唑啉酮类化合物的合成及其生物活性

Synthesis and Bioactivity of Substituted 3H-Benzoxazol-2-ones

摘要: 采用邻氨基酚为原料合成了N-酰基苯并噁唑啉酮类化合物30个,其化学结构经1H NMR及元素分析确证。初步的生物活性试验结果表明,该类化合物具有一定的杀虫、杀菌活性,其中化合物 3b、4b、14b、19b 在50 mg/L浓度下对淡色库蚊Culex pipiens pallens 的致死率为100%,有7个化合物在1 000 mg/L浓度下对朱砂叶螨Tetranychus cennbarinus的致死率达95%以上。

Abstract: Thirty novel 3H-benzoxazol-2-ones were designed and synthesized. Their structures were confirmed by 1H NMR and elemental analysis. The preliminary bioassay showed that the compounds synthsized had insecticidal and fungicidal activities. The mortality of compounds 3b,4b,14b,19b to Culex pipiens pallens at the concentration of 50 mg/L reached 100%, the mortality rate of Tetranychus cennbarinus by some compounds at the concentration of 1 000 mg/L were all over 95%.