Abstract: In order to synthesis some compounds with better fungicidal activity, the reaction of 3-aryl-4-amino-5-mercapto-1,2,4-S-triazoles with α-thiophaldehyde in the presence of absolute actonitrile were investigated and ten Schiff bases of triazole and thiophene were obtained by microwave method and traditional method in comparison. Their structures were comfirmed by elemental analysis,IR, 1H NMR and MS. The results to six kinds of pathogenic species of the biological test showed that the compounds IIe and IIf had good inhibitory activities (inhibition rate≥62%) and all of the compounds showed good inhibitory activities (inhibition rate≥85%) to Dothiorella gregaria and Rhizoctonia solani at 50 mg/L.