梅向东, 杨国权, 宁君. 利用簇合效应发现和创制高效新农药的设想[J]. 农药学学报, 2006, 8(3): 203-208.
    引用本文: 梅向东, 杨国权, 宁君. 利用簇合效应发现和创制高效新农药的设想[J]. 农药学学报, 2006, 8(3): 203-208.
    MEI Xiang-dong, YANG Guo-quan, NING Jun. The New Approach on Screening Pesticides Using Cluster Effect[J]. Chinese Journal of Pesticide Science, 2006, 8(3): 203-208.
    Citation: MEI Xiang-dong, YANG Guo-quan, NING Jun. The New Approach on Screening Pesticides Using Cluster Effect[J]. Chinese Journal of Pesticide Science, 2006, 8(3): 203-208.

    利用簇合效应发现和创制高效新农药的设想

    The New Approach on Screening Pesticides Using Cluster Effect

    • 摘要: 基于以下理论提出了一种创制高活性新农药的观点:将一种活性寡糖小分子制成簇合物后,其活性有时可大大增加,即产生了簇合效应(cluster effect)。通过列举簇合效应在医药领域成功应用的事例,指出其在高活性新农药创制中应用的可能性。预期这一机制可用于筛选和发现高效新农药。

       

      Abstract: A new approach to design new pesticides was introduced.It was based on the data that in some cases oligosaccharide molecules in cluster form display much higher bioactivity than the corresponding oligosaccharide molecules.That was called "cluster effect".The activities of some polymers of medicine that was significantly enhanced by their "multivalent" or "cluster effects" were inumerated.It was anticipated that the mechanism of cluster effect could be used to screen and create highly active pesticides.

       

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