Abstract: In search of novel pesticide leading compound with high bioactivity,thirty-five 4-chloro-phenyl methyl ketone oxime ether derivatives were designed and synthesized by the reaction of 2-substituted amino 4-chlorophenyl methyl ketone oxime with halohydrocarbon.The structure of all novel compounds was confirmed by 1H NMR and elemental analysis.Preliminary bioassays showed that some compounds exhibited certain insecticidal and herbicidal activities.The mortality of C9,C12 to Aphis craccivaora reached 100% at the concentration of 500 mg/L.The mortality of C10,C12,C15 and C23 to Tetranychus cinabarinus reached 100% at 1 000 mg/L.The inhibition rate of C29,C30 and C31 to Sphaerotheca fuligineas was over 95% at the concentration of 500 mg/L.The inhibition rate of C29,C30,C33 and C35 to Digitaria sanguinalis was over 90% at the concentration of 100 mg/L.