新的吡啶杂环硫代磷酸酯类化合物的合成及杀虫活性

Synthesis and Insecticidal Activity of a Novel Pyridine-heterocyclic Thiophosphate Compounds

摘要: 为了寻找高活性的新化合物,通过相转移催化反应,在二氯甲烷/水体系中合成了一系列新的吡啶杂环硫代磷酸酯类化合物,其结构均经1H NMR、13C NMR、31P NMR、IR和MS的表征,并通过元素分析确证。室内生物活性测试结果表明,部分化合物表现出较好的杀虫活性,其中化合物 3a 对苜蓿蚜Aphis medicaginis Koch和化合物 3c 对东方粘虫Mythimna separate的 LC50值分别为 1.64和 0.73 mg/L,与对照药剂毒死蜱的活性相当。

Abstract: In search of novel compounds with high bioactivities,a series of pyridine-heterocyclic thiophosphate compounds were synthesized in CH2Cl2/H2O system catalyzed by tetrabutyl ammonium bromide. All compounds were confirmed by 1 H NMR,13C NMR,31P NMR,IR,MS and elemental analysis. The bioassay results show that the compounds have good insecticidal activity.The LC50 value of compound 3a against Aphis medicaginis Koch and 3c against Mythimna separata were 1.64 and 0.73 mg/L, respectively. The control effects were equal to the treatment of chlorpyrifos.