Abstract: A series of benzoyl methanesulfonamides have been synthesized.They were obtained by sulfonation,chlorization,amination from the readily available acetophenone.Their structures were confirmed by 1H NMR,IR and elementary analysis.The bioassay indicated that some of them possess certain fungicidal activity against Botrytis cinerea,Gibberlla zeae,Rhizoctonia solani,Venturia nashicola at a dose of 50 μg/mL.The EC50 value of title compounds B-8、B-9、B-10、B-12 was reached 1.0,0.2,1.2 and 0.4 μg/mL against B.cinerea,the effect was approximated or better than pyrimethail and EC50 value of title compounds B-8、B-10、B-11 was reached 0.07,0.2 and 0.05 μg/mL against G.zeae,the effect was better than carbendazim.