Abstract: A novel compound,a derivative of 2-pyrimidinyloxy-N-arylbenzylamine was designed and synthesized by using 2,5-dichloroaniline,6-chloro-salicylic aldehyde and 4,6-dimethoxy-2-methyl sulfonyl pyrimidine.The chemical structure of the compound was confirmed by 1H NMR,MS and elemental analysis.The bioassay indicated that it had good herbicidal activity to the important weeds in cotton field,such as Echinochloa crusgalli,Digitaria sanguinalis,Setaria viridis,Amaranthus retroflexus and Brassica juncea,the inhibition rate were 80% ~100% at 75 g(a.i.)/hm2,and it was safe to cotton,no obvious crop injury was observed at 225 g(a.i.)/hm2. The selectivity coefficient between cotton and sensitive weed Amaranthus retroflexus was 24.93.It had a good potential to be and applicaed value in cotton field.