吡啶衍生物研究Ⅷ:2-烷氨基-5-(2-芳氧吡啶-3-基)-1,3,4-噻二唑类衍生物的合成与及生物活性

Studies on pyridine derivatives (Ⅷ):Synthesis and bioactivity of 2-alkylamino-5--1,3,4-thiodiazoles (1.College of Science,China Agricultural University,Beijing 100193,China; 2.Institute of Plant Protection,Chinese Academy of Agricultural Science,Beijing 100193,China)

摘要: 以2-取代苯氧基烟酰肼为原料,与异硫氰酸酯反应合成了14个结构新颖的2-烷氨基-5-(2-芳氧吡啶-3-基)-1,3,4-噻二唑类化合物,其结构通过 1H NMR、IR和元素分析表征。初步生物活性测试结果表明,化合物 4j 在50 mg/L下对黄瓜枯萎病菌Cladosporium cucumerium的抑制率可达70％。

Abstract: Fourteen novel title compounds were synthesized from 2-substituted phenoxy isonicotinyl hydrazide with isothiocyanate.The structures of the compounds were confirmed by 1H NMR,IR and elemental analysis.The preliminary fungicidal bioassay results showed that the inhibition rate of 4j against Cladosporium cucumerium was 70％ at the concentration of 50 mg/L.