Abstract: Different clean-up methods,including packing column,solid phase extraction,gel permeation chromatography,sulfonation,mixture solid phase disperse and so on,were introduced.Then,the utilized of those clean-up techniques in the residue analysis of organochlorine pesticides(OCPs) in water,soil,sediment,tea-leaf,Chinese medicine and fatty sample were introduced according to the type of the matrix after consulting lots of literatures and author's work experience.It was believed that various purification techniques could be well combined with extraction techniques or detection techniques.This is useful to increase the whole analysis speed and will be the development trend of purification technique for OCPs.