张琨, 宋成荣, 廖国辉, 杨新娟, 周文明. 1-甲基-3-二氟甲基吡唑酰胺类化合物的合成及抑菌活性[J]. 农药学学报, 2011, 13(6): 576-580.
    引用本文: 张琨, 宋成荣, 廖国辉, 杨新娟, 周文明. 1-甲基-3-二氟甲基吡唑酰胺类化合物的合成及抑菌活性[J]. 农药学学报, 2011, 13(6): 576-580.
    ZHANG Kun, SONG Cheng-rong, LIAO Guo-hui, YANG Xin-juan, ZHOU Wen-ming. Study on synthesis and antifungal activity of 1-methyl-3- difluoromethyl pyrazolamide derivatives[J]. Chinese Journal of Pesticide Science, 2011, 13(6): 576-580.
    Citation: ZHANG Kun, SONG Cheng-rong, LIAO Guo-hui, YANG Xin-juan, ZHOU Wen-ming. Study on synthesis and antifungal activity of 1-methyl-3- difluoromethyl pyrazolamide derivatives[J]. Chinese Journal of Pesticide Science, 2011, 13(6): 576-580.

    1-甲基-3-二氟甲基吡唑酰胺类化合物的合成及抑菌活性

    Study on synthesis and antifungal activity of 1-methyl-3- difluoromethyl pyrazolamide derivatives

    • 摘要: 以1-甲基-3-二氟甲基吡唑-4-甲酸为原料,经过1-甲基-3-二氟甲基吡唑-4-甲酰氯与相应的氨基苯并杂环类、芳胺类化合物反应,得到了14个未见文献报道的吡唑-4-甲酰胺类化合物(6a~6g、7a~7g),其结构均通过1H NMR、MS和IR表征。抑菌活性测试结果表明,在100 mg/L下,目标化合物对供试植物病原菌均有不同程度的抑制作用,其中7a~7g的抑菌活性较高,部分对苹果炭疽病菌的抑制率在90%以上。

       

      Abstract: Fourteen novel pyrazol-4-amide derivatives were synthesized from 3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxylic acid by the reaction of 3-difluoromethyl-1-methyl-1 H-pyrazole-4-carbonyl chloride with various amines.The structures of these compounds were confirmed by 1H NMR,MS,and IR.Antifungal activity test indicated that all of the synthesized compounds (6a-6g,7a-7g) showed different inhibition on tested plant pathogenic fungi at the concentration of 100 mg/L.The compounds 7a-7g exhibited good antifungal activity,and the growth inhibition rate of compounds 7a,7d,7g against Glomerella cingulata was above 90%.

       

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