新型含2(1H)-喹啉酮的甲氧基丙烯酸酯类

Synthesis and antifungal activity of novel strobilurin compounds containing 2(1H)-quinolinone

摘要: 以(E)-2-2'-(bromo-methyl)phenyl3-甲氧基丙烯酸甲酯和2(1H)-喹啉酮类化合物为原料,通过醚化等反应,合成了11个新型含2(1H)-喹啉酮结构的甲氧基丙烯酸酯类化合物,其结构经红外、电喷雾串联质谱(ESI-MS)和核磁共振氢谱确证。初步生物活性测试结果表明:在100 mg/L质量浓度下,部分目标化合物对烟草赤星病菌Alternaria alternata等6种病原菌具有一定的抑菌活性,其中5a对水稻稻瘟病菌Pyricularia grisea的抑菌率达100%。

Abstract: Eleven novel strobilurin compounds were synthesized from(E)-methyl 2-2'-(bromo-methyl)phenyl-3-methoxyacrylate and 2(1H)-quinolinone as materials via etherification,etc.The structures of all compounds were confirmed by IR,ESI-MS,1H NMR.Antifungal activity test showed that the compound 5a,5d and 5e exhibit certain inhibiting effect against all the tested strains at the concentration of 100 mg/L,and 5a showed 100% inhibition rate against Pyricularia grisea.