王向辉, 尹学琼, 冯文, 杨建新, 林强. N-取代苯基-2-(苯并异噻唑啉-3-酮-2-基)甲酰胺的合成及抑菌活性[J]. 农药学学报, 2012, 14(2): 225-228.
    引用本文: 王向辉, 尹学琼, 冯文, 杨建新, 林强. N-取代苯基-2-(苯并异噻唑啉-3-酮-2-基)甲酰胺的合成及抑菌活性[J]. 农药学学报, 2012, 14(2): 225-228.
    shu
    WANG Xianghui, YIN Xueqiong, FENG Wen, YANG Jianxin, LIN Qiang. Synthesis and antibacterial and fungicidal activity of 3-oxo-N-arylbenzo[d]isothiazole-2(3H)-carboxamides[J]. Chinese Journal of Pesticide Science, 2012, 14(2): 225-228.
    Citation: WANG Xianghui, YIN Xueqiong, FENG Wen, YANG Jianxin, LIN Qiang. Synthesis and antibacterial and fungicidal activity of 3-oxo-N-arylbenzo[d]isothiazole-2(3H)-carboxamides[J]. Chinese Journal of Pesticide Science, 2012, 14(2): 225-228.
    shu

    N-取代苯基-2-(苯并异噻唑啉-3-酮-2-基)甲酰胺的合成及抑菌活性

    Synthesis and antibacterial and fungicidal activity of 3-oxo-N-arylbenzodisothiazole-2(3H)-carboxamides

      摘要
    • 摘要: 通过取代苯异氰酸酯与1,2-苯并异噻唑啉-2(3H)-酮(BIT)反应,制备了13个2-(苯并异噻唑啉-3-酮-2-基)甲酰胺类化合物,其中9个未见文献报道。所有化合物的结构均经IR、1H NMR和元素分析确认。初步的抑菌活性测定结果表明,部分目标化合物对供试病原菌具有很好的抑菌活性,尤其对于枯草芽孢杆菌Bacillus subtilis和芒果蒂腐病菌Botryodiplodia theobromae,大部分化合物在50 mg/L下的抑制率在80%~100%之间。

       

      Abstract: Thirteen 3-oxo-N-arylbenzodisothiazole-2(3H)-carboxamide derivatives were synthesized via reaction of 1,2-benzisothiazol-2(3H)-one with substituted phenyl isocyanate.Among them nine compounds were not reported.Their structures were confirmed by elemental analyses,IR and 1H NMR.Priliminary bioassays showed that some of the compounds exhibit 80%-100% inhibition rate against Bacillus subtilis and Botryodiplodia theobromae at the concentration of 50 mg/L.

       

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