马来松香酸酰腙类化合物的合成及杀菌活性

Synthesis and fungicidal activity of maleated rosin acid acylhydrazone compounds

摘要: 以马来松香酸为原料,经酰氯化和肼解反应制备了马来松香酸酰肼(3),3 与取代苯甲醛通过缩合反应合成了11个未见文献报道的马来松香酸酰腙类化合物 4a~4k, 其结构均经 IR、1H NMR、13C NMR和元素分析表征和确证。初步的生物活性测定结果表明:目标化合物在质量浓度为50 μg/mL下对5种供试植物病原菌均有不同程度的杀菌活性,其中化合物 4e (R=4-CH3OC6H4)对小麦赤霉病菌Gibberella Zeae的抑制率达68.3%。

Abstract: Maleated rosin acid hydrazide (3) was prepared via acyl chlorination and hydrazinolysis using maleated rosin acid as starting material,followed by condensation of 3 with phenyl aldehydes to afford eleven novel maleated rosin acid acylhydrazones 4a-4k. Their structures were confirmed by IR,1H NMR,13C NMR and elemental analysis.The preliminary bioassay showed that,all the target compounds exhibited different fungicidal activity against five fungi tested at the concentration of 50 μg/mL,in which compound 4e (R=4-CH3OC6H4)had the best inhibition rate of 68.3% against Gibberella Zeae.