3'-烷基- α -三联噻吩的合成及其杀线虫活性

Synthesis and nematocidal activity against Panagrellus redivivus of 3'-alkyl- α -terthiophene

摘要: 以3-溴噻吩为原料,以Kumada偶联反应和Suzuki偶联反应为关键步骤合成了9个3'-烷基- α -三联噻吩类化合物 8~16,其中5个为新化合物,其结构经1H NMR、MS和元素分析的表征和确证。采用光照法首次测定了9个合成化合物对全齿复活线虫Panagrellus redivivus的杀伤率。结果表明:除化合物13外,其余目标化合物在50 μg/mL、照度为2 000 lx、光照时间为72 h条件下对全齿复活线虫的杀伤率均在85%以上。

Abstract: Starting from 3-bromothiophene,a series of 3'-alkyl- α -terthiophene derivatives(8-16) were synthesized via Kumada coupling reaction and Suzuki coupling reaction as key steps.Five of them were first reported.Their structures were identified by 1H NMR,MS and elemental analysis.The illumination method was used to test the nematocidal activity against Panagrellus redivivus of these compounds for the first time.The results showed that these compounds exhibited more potent nematocidal activity except compound 13,under the condition of a concentration of 50 μg/mL,the light intensity of 2 000 lx,light time of 72 hours.The nematocidal activity of these compounds was above 85% except compound 13.