橙酮类似物的合成及抑菌活性

Synthesis and antifungal activity of analogues based on aurone

摘要: 以芝麻酚和芳香醛为主要原料,经傅-克酰基化、关环和羟醛缩合反应,设计合成了14个未见文献报道的橙酮类似物,其结构均经1H NMR、MS和IR确证。初步抑菌活性测定结果表明:在100 mg/L下,所有目标化合物对7种供试病原菌均有不同程度的抑制作用,其中化合物 3a、3b、3c和3d 对番茄灰霉病菌Botrytis cirerea的抑制率达到100%, 3g 对小麦赤霉病菌Fusarium graminearum、玉米弯孢叶斑病菌Curvulavia lunata、棉花枯萎病菌Fusarium oxysporum vasinfectum、水稻稻瘟病菌Magnaporthe grisea的抑制率均大于80%, 3m 对马铃薯干腐病菌Fusarium solani和玉米弯孢叶斑病菌的抑制率分别为100%和83.8%。

Abstract: Fourteen novel aurone analogues were synthesized from sesamol and aromatic aldehyde by the reaction of Friedel-Crafts acylation,cyclization and aldol condensation.The structures were confirmed by 1H NMR,IR and MS.Preliminary bio-activity test showed that fourteen compounds exhibit different inhibitory effect against all the tested fungi at concentration of 100 mg/L.Compounds 3a-3d had 100% inhibitory effect against Botrytis cirerea.Compound 3g showed good inhibition to Fusarium graminearum,Curvulavia lunata,Fusarium oxysporum vasinfectum and Magnaporthe grisea,the inhibition rate were above 80%.The inhibition rate of compound 3m to Fusarium solani and C.lunata was up to 100% and 83.8%,respectively.