N-4-叔丁基-6-芳基-5-(1,2,4-三唑-1-基)-1,3-噻嗪-2-基酰胺类化合物的合成及抑菌活性

Synthesis and antifungal activity of novel N-4-tert-butyl-6-aryl-5-(1,2,4-triazol-1-yl)-1,3-thiazin-2-yl amides

摘要: 以α-三唑基频那酮为起始原料,经缩合、环化和酰胺化反应合成了15个未见文献报道的化合物,其结构均经核磁共振氢谱、红外光谱和质谱确认。初步抑菌活性测试结果表明,在50 mg/L下,目标化合物对供试植物病原菌均有不同程度的抑制作用,其中化合物3a-3、3a-4、3a-5、3b-2和3b-3对番茄灰霉病菌Botrytis cinerea的抑制率达80%以上,3a-4和3a-5对棉花枯萎病菌Fusarium oxysporum vasinfectum的抑制率分别达78.6%和82.4%。

Abstract: 15 Novel compounds were synthesized from α-triazole pinacolone by condensation reaction,cyclization reaction and amidation reaction.Their structures were confirmed by IR,1H NMR and MS.The preliminary bioassay showed that all of the synthesized compounds have different inhibition on six tested plant pathogenic fungi at the concentration of 50 mg/L.The inhibition rates of compound 3a-3,3a-4,3a-5,3b-2 and 3b-3 against Botrytis cinerea were up to 80%. 3a-4 and 3a-5 were 78.6% and 82.4% against Fusarium oxysporum vasinfectum respectively.