Semisynthesis of spinosyn B

LAI Qing; OU Xiaoming; PEI Hui; LIU Suyou; MA Dayou

doi:10.16801/j.issn.1008-7303.2016.0039

LAI Qing, OU Xiaoming, PEI Hui, LIU Suyou, MA Dayou. Semisynthesis of spinosyn B[J]. Chinese Journal of Pesticide Science, 2016, 18(3): 299-303. DOI: 10.16801/j.issn.1008-7303.2016.0039

Citation:

LAI Qing, OU Xiaoming, PEI Hui, LIU Suyou, MA Dayou. Semisynthesis of spinosyn B[J]. Chinese Journal of Pesticide Science, 2016, 18(3): 299-303. DOI: 10.16801/j.issn.1008-7303.2016.0039

Citation:

LAI Qing, OU Xiaoming, PEI Hui, LIU Suyou, MA Dayou. Semisynthesis of spinosyn B[J]. Chinese Journal of Pesticide Science, 2016, 18(3): 299-303. DOI: 10.16801/j.issn.1008-7303.2016.0039

Semisynthesis of spinosyn B

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Spinosyn B bears very potent insecticidal acitivity. However, it is difficult to obtain because of its low concentration in natural. In this paper, spinosyn B was successfully synthesized from spinosyn A, the major component in spinosad, utilizing iodine, sodium acetate and sodium hydroxide as reagents and methanol as the solvent. After optimization, the yield has been improved to 81%. The structure of spinosyn B was confirmed by 1H NMR, 13C NMR and HRESI-MS.

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