Synthesis and bioactivity of (S, S)-2,8-diazabicyclo 4.3.0 nonane containing benzimidazole moiety

A series of novel (S, S)-2,8- diazabicyclo 4.3.0 nonane containing benzimidazole moiety was synthesized and their structures were determined by 1H NMR and HRMS. The biological activity results showed that these compounds possessed moderate antifungal activity to some plant pathogenous fungi and moderate insecticidal activity against Mythimna separata Walker and Culex pipiens pallens. Compounds 6e and 6f exhibited good antibacterial activity against Sclerotinia sclerotiorum, Phytophthora infestans and Fusarium graminearum. The lethality rates of compounds 6e and 6k against Mythimna separata Walker were 100% at 200 mg/L and the lethality rates of compounds 6h and 6k against C. pippiens pallens were 75% at 2 mg/L.