Synthesis and fungicidal activity of novel N-aryl-2-((5-((4,6-dimethylpyrimidin-2-yl)thiomethyl)-1,3,4-thiadiazole-2-yl)thio)-acetamide compounds

In order to discover novel heterocyclic compounds with biological activities, ten novel N-aryl-2-((5-((4,6-dimethylpyrimidin-2-yl)thiomethyl)-1,3,4-thiadiazole-2-yl)thio) acetamide compounds were synthesized under microwave assisted condition via cyclization, esterification, hydrazination, cyclization and the condensation reactions. The structures of the title compounds were characterized by 1H NMR, 13C NMR, IR, ESI-MS and elemental analysis. The preliminary bioassay results indicated that most of them showed inhibition activity against Colletotrichum orbiculare, Botrytis cinerea and Rhizoctonia solani at the concentration of 50 mg/L. The inhibition rate of compound 8h against C. orbiculare reached 77.3%.