Toxicityofforchlorfenuronforfour-weekoraladministrationinSDrats

To study the toxic effects of forchlorfenuron in SD rats, rats were given forchlorfenuron daily at the dose of 150, 300 and 600 mg/kg for 4 weeks by oral administration. The general state and death of rats were observed daily, and the body mass and food intake were recorded weekly. Rats were sacrificed on either the 1st or 15th day after drug withdrawal. Serum biochemical indexes and coagulation parameters were measured. The major organ indexes were determined and histopathology was detected. The results showed that: there was no significant effect of forchlorfenuron on body mass on food intake, on blood routine and on parameters of blood coagulation of rats for four-week oral administration. On 1st day after drug withdrawal, compared with solvent control group, the urea nitrogen and creatinine of the male rats in the forchlorfenuron 300 mg/kg and above group were significantly increased (P < 0.05), and the blood glucose levels in the 600 mg/kg dose group were also increased (P < 0.05). The urea nitrogen, creatinine, and blood glucose of male rats in the 600 mg/kg treatment group were respectively 1.9, 1.6 and 1.3 times higher than those in the control group. The kidney coefficients of female and male rats in 300 mg/kg and above treatment group were significantly increased (P < 0.05), in which the kidney coefficients of the female and male rats in the 300 mg/kg treatment group were 1.2 and 1.1 times higher than those in the control group respectively, the kidney coefficients of the female and male rats in the 600 mg/kg treatment group were 1.4 and 1.1 times higher than those in the control group respectively. The liver coefficient of the female rats in the 300 and 600 mg/kg treatment group were significantly increased (P < 0.01), which were 1.3 and 1.9 times higher than those in the control group respectively .The pathological histologic changes of the kidney were shown in the pathological section. The main manifestations were mild renal tubular atrophy, obvious leucotype, transparent tube type, interstitial inflammatory cell infiltration, and renal tubular expansion. On the 15th day, the symptoms of toxicity were recovered. SD rats were administered with forchlorfenuron for 4 weeks, it shows that there was significant renal toxicity at a dose of 600 mg/kg and a mild renal toxicity at a dose of 300 mg/kg, and the main toxic target organ may be the kidney. No obvious toxic reaction dose of forchlorfenuron was 150 mg/kg dose.