XIE Jingyu, ZHANG Guilong, YU Zhiguo. Bistetrahydrofuran lignans isolated from Artemisia lavandulaefolia DC and their antifungal activities[J]. Chinese Journal of Pesticide Science, 2019, 21(3): 383-388. DOI: 10.16801/j.issn.1008-7303.2019.0036
    Citation: XIE Jingyu, ZHANG Guilong, YU Zhiguo. Bistetrahydrofuran lignans isolated from Artemisia lavandulaefolia DC and their antifungal activities[J]. Chinese Journal of Pesticide Science, 2019, 21(3): 383-388. DOI: 10.16801/j.issn.1008-7303.2019.0036

    Bistetrahydrofuran lignans isolated from Artemisia lavandulaefolia DC and their antifungal activities

    • In order to discover novel botanical fungicides, the chemical constituents of the aerial parts of Artemisia lavandulaefolia DC. were investigated. The aerial parts were extracted with methanol. By using liquid-liquid extraction, column chromatography, high performance preparative liquid chromatography and other techniques, 6 pure compounds were finally isolated from the ethyl acetate phase. The compounds were identified as bistetrahydrofuran lignans, including epiashchantin ( 1 ), ashantin ( 2 ), sesartemin ( 3 ), epimagnolin A ( 4 ), epiyangambin ( 5 ) and diayangambin ( 6 ), according to NMR and MS data. The mycelium growth rate method was used to determine the antifungal activities. The results showed that compound 1 and 3 significantly inhibited the growth of Alternaria solani with the EC50 value of 14.3 μg/mL and 11.0 μg/mL, respectively. Compound 3 , 5 and 6 also showed inhibitory effect against the mycelia growth of Rhizoctonia solani with the EC50 value of 17.4, 42.6 and 54.3 μg/mL, respectively.
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