Research advances in the insecticidal plant Periploca sepium

Periploca sepium, a traditional insecticidal plant, belongs to Asclepiadaceae and is widely distributed in China. It is considered as a potential botanical pesticide because of the significant insecticidal activity of its secondary metabolites. In this review, the insecticidal and antimicrobial activities, main insecticidal active ingredients, mechanism of action, and preparations development and application of P. sepium were reviewed. And combining with the author's work, it highlighted the research progress about the target identification and verification of the main insecticidal compound periplocoside P acting on the midgut cell membrane of Mythimna separata larvae. Finally, the potential application of P. sepium as a commercial pesticide was prospected, which provided a reference for the development of green pesticides in China.