Advances in pesticide poisoning mechanism based on multi-omics

China is a big agricultural country. The food supply stability is heavily relied on the agriculture advancement. Despite the usage of pesticides has ensured the stable crop yield, the increasing usage of pesticide has resulted in long-term negative impacts on the environmental and food safety. Thus, the risk assessment and management of pesticides have called for increasing attention of researchers. Multi-omics is a promising tool for identifying the mode of action of bioactive compounds in pharmaceutical industry. However, few studies have applied this approach in the risk assessment and mechanisms of toxic in pesticides. In this review, the progress in the mode of toxic action identification of the pesticides by various omics approaches has been summaried. Based on the previous research, some key biomarkers and their corresponding regulatory pathways were identified, and the potential mode of toxic actions and application of risk management of pesticides were explored.