Structural identification and synthesis of main impurities in tefuryltrione

In the preparation of tefuryltrione, three main impurities over 0.1%(wt) were detected by high-performance liquid chromatography. The structures of impurities were characterized by ¹H NMR and HRMS. Two of those compounds were novel compounds. Then the impurities were synthesisezed by the modified synthetic route of tefuryltrione. The work will contribute to the quality control and safety production of tefuryltrione.