Synthesis and fungicidal activity of cyclohexanamide derivatives with triazole moeity

In order to discover novel compounds with high fungicidal activities, a series of new compounds were designed using macrocyclic compound   Z13-5   as the lead compound. And the triazole and cyclohexanamide moeities were retained. 26 new target compounds were synthesized through azidation, azic-alkyne click reaction, etc, and characterized by ¹H NMR, ¹³C NMR and HRMS spectral data. Preliminary bioassay indicated that fungicidal activities of the target compounds were lower than compound   Z13-5  . At the concentration of 50 mg/L, the inhibition rates of most of the target compounds to the tested pathogenic fungi were less than 50%, except   7g   had 91% inbition rate to Phytophthora capsicum.