Determination and chronic dietary exposure assessment of procymidone residue in Chinese chives

An effective method was developed for the determination of procymidone residue in Chinese chives by QuEChERS combined with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The supervised residue field trials of procymidone were designed and conducted in China (Heilongjiang, Liaoning, Henan, Shandong, Anhui, Hunan, Guangxi, and Fujian Province) in 2019. The risk of residue of procymidone applied in Chinese chives was studied, and the chronic dietary exposure risk of procymidone was evaluated. The samples were extracted by acetonitrile, purified with PSA and GCB, detected using HPLC-MS/MS, and quantified by external standard method. The recoveries ranged from 74% to 98% with the relative standard deviations (RSD) of 4.6%-9.9% at the fortified levels of 0.02 to 20 mg/kg. The limit of quantitation (LOQ) of the method was 0.02 mg/kg. The field trial results showed that after the spraying of 50% wettable powders (WP) of procymidone at 450 g a.i./ hm² once, the final residues in Chinese chives from 8 provinces were 0.04-1.06 mg/kg at 30 days after the application. Given that the national estimated daily intake (NEDI) of procymidone was 2.5562 mg, its risk quotient (RQ) was 40.6%. The result of the chronic dietary exposure assessment revealed that it might not pose an unacceptable risk to the general population’s health by applying procymidone on Chinese chives.