Rapid determination of 47 pesticide residues in Folium Archidendri by SPE- high performance liquid chromatography-tandem mass spectrometry

In this work, a method was developed for the determination of 47 pesticide residues in Folium Archidendri using HLB solid phase extraction by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Electrospray ionization source was applied by positive ionization (ESI⁺) in scheduled multiple reaction monitoring modes. The samples were extracted with acetonitrile by high speed homogenizer, purified by HLB SPE, and analyzed quantitatively by matrix-matched external standard curve method. The calibration curves of 47 targets showed good linearity with correlation coefficients of above 0.9920. The average recoveries were in the range of 54%-117%, with RSDs of 2.0%-15%. LOQs of all the tested pesticides were 0.001-0.015 mg/kg. Among them, the recoveries of 40 pesticides were in the range of 70%-120%, which met the requirements of multi-pesticides trace analysis. This analytical method was simple, quick, stable and sensitive, which could be used for a monitoring and screening analysis of multi-pesticide residues in Folium Archidendri.