Research progress on insect short neuropeptide and its potential applications in pest control
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Graphical Abstract
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Abstract
Insect short neuropeptide F (sNPF) is a class of neuropeptides unique to insects, named for its C-terminal phenylalanine (F). These peptides are composed of 6-19 amino acids and have a conserved C-terminal RLRFamide structure. sNPF is involved in regulating various physiological activities in insects, including feeding, growth and development, circadian rhythms, water-salt balance. Its receptor is a class A G protein-coupled receptors (GPCR-As) with typical seven transmembrane domains. By binding to receptor sNPFRs, sNPF plays an important regulatory role in the insect nervous system. This article primarily reviews the research progress on sNPF, including its structure and function, as well as the potential applications in pest control. The aim is to provide guidance for the design and modification of lead compounds based on short neuropeptide sNPF, as well as supporting the research and development of novel green pesticides, thereby offering new ideas and methods for agricultural pest management.
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