Synthesis and antifungal activity of kojic acid and chlorokojic acid derivatives

Sixteen kojic acid derivatives (QⅠ-01~QⅠ-16) and ten chlorokojic acid derivatives (QⅡ-01~QⅡ-10) were synthesized from kojic acid. The structures of the synthesized derivatives were confirmed by 1H NMR and elemental analysis. Antifungal activity results indicated that all of the title compounds exhibited variable inhibitory activities against the mycelial growth of Glomerella cingulata and Botrytis cinerea. The inhibition rates of 50 μg/mL QⅠ-07 and QⅠ-11 against G.cingulata were 79.3% and 86.2%, and QⅡ-04, QⅡ-08 and QⅡ-09 against B.cinerea were 70.0%, 70.0% and 76.6%, respectively.