Research progress on bioeffect and toxicology of insecticide fluralaner and its derivatives

Fluralaner acts as a novel type of isoxazoline insecticides by interfere with γ-aminobutyric acid(GABA) gated chloride channel. It displays remarkable differences in molecular structure, site of action, selectivity and cross-resistance comparing to cyclodience, phenylpyrazole and macrolides insecticides which have similar mode of action in interfering with GABA gated chloride channel. The invention, toxicity, insecticidal spectrum and mechanism of fluralaner were summarized. The prospect of fluralaner and isoxazoline insecticides were also included.