Synthesis and biological activities of purinoxy-phenoxy- propionate derivatives

Using 4,6-dichlone-5-nitro pyrimidine as starting material, 11 novel purinoxy-phenoxy- propionate derivatives 1a-1k were synthesized by reductive amination, substitution and etherification. Structures were characterized by 1H NMR and MS spectra. Preliminary results showed that all of compounds displayed herbicidal activities at the concentration of 200 mg/L. The inhibition rate of 1f ((R)-butyl-2-(4-((9-(4-chlorophenyl)-8-(trifluoromethyl-9H-purin-6-yl)oxy)phenoxy)propanoate) and 1h ((R)-ethyl-2-(4-((9-(4-chlorophenyl)-8-(trifluoromethyl-9H-purin-6-yl)oxy)phenoxy)propanoate) almost reached 100%.