Synthesis and bioactivities of sulfinic esters containing substituted isoxazolyl moieties

In order to secure novel sulfinic esters with unique biological activities, new compounds were obtained by introducing isoxazole moiety into propargite. Thus, 12 novel compounds(ZJ1-ZJ12)were synthesized by 1,3-dipolar cycloaddition reaction of substituted chlorinated oximes(3) and propargite. Structures of these compounds were confirmed by MS and 1H NMR. The preliminary bioassay showed that most compounds exhibit good insecticidal and herbicidal activity. The activity of compound ZJ12 against Tetranychus cinnabarinus was as high as propargite. The mortality can reach 75% at a concentration of 125 mg/L. Compound ZJ10 showed 100% inhibitory rates against all the target plants at a concentration of 200 mg/L and the activity of which was better than pyribambenz isopropyl.