Synergistic Mechanism of NIA16388 to Deltamethrin in Deltamethrin-Resistant Housefly (Muscadomestica)

Synergism of NIA16388(NIA ) to deltamethrin in housefly of Del-R strain was studied. Result of bioassay showed that synergistic rate of N IA to deltamethrin was 214.60. The synergistic mechanism of NIA was also researched. The results suggested that: (1)NIA inhibited Carboxylesterase(CarE) activities significantly and I50 value to CarE were 2.14(±0.22)×10-7 mol·L-1 (α-NA) and 1.09(±0.39)×10-9 mol·L-1 (β-NA),respectively; (2)The inhibition of MFO activity by NIA was 78.63(±0.13)% when NIA concentration was 4.20×10-4mol·L-1; (3)NIA could inhibit AChE activity and I50 value was 2.37(± 0.69 )×10-5 mol·L-1. Accordingly NIA is considered a muti-target synergistic agent.