Synthesis and Identification of Antigenic Conjugate against Parathion-methyl

Four kinds of hapten with the similar structure of parathion-methyl were designed and synthesized. These four haptens were coupled with different length and structural spacer arms through nitro-group or methoxyphosphate group of parathion-methyl. Then six kinds of hapten-protein conjugates were synthesized by different methods. The immune program yielded high specific and high affinity antibodies for parathion-methyl.