Synthesis and Structure Elucidation of the Celangulin Analogues

In order to look for new active compounds,celangulin analogues were synthesized based on the basic hydrolysis of the extract of the root bark of Celastrus angulatus Max. and isolated by bioassay-guided fractionation. Two new active compounds were synthesized and isolated. Their structures were comfirmed as 2β,6α,8β,13-tetraisobutanoyloxy-1β,4α,9α-trihydroxy-β-dihydroagarofuran (A) , 1β,2β,6α,8β,13-pentaisobutanoyloxy-4α,9α-dihydroxy-β-dihydroagarofuran (B) based mainly on NMR and MS spectral data. A and B are new compounds with insecticidal activity against Mythimna soparata.