Synthesis and Fungicidal Activities of N-Carboalkoxy(aryloxy)-2-thiazolidinones

In order to find new fungicidal lead compounds, eleven N-carboalkoxy(aryloxy)-2-(thiazolidinones,) ten of which are novel compounds, were prepared from a condensation reaction of (2-thiazolidinone) and chloroformate, and their structures were confirmed by ~(1)H NMR, MS, IR and (elemental) analysis. The results of fungicidal tests, at the concentration of 2 000 mg/L, indicated that some of them exhibited good activities toward various plant disease fungi. Compounds 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j showed excellent inhibitory activities (100%) against Sclerotinia sclerotiorum. (Compound) 5i showed excellent inhibitory activities (100%) against Botrytis cinerea, Penicillium (italicum) and S. sclerotiorum, and also showed inhibitory activities against Xanthomonas oryzae, Pseudomonas solanacearum.