Synthesis and Bioactivity of 1-Substitutedanilino-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one

In order to search for the active alkenyl triazole fungicide, a series of novel 1-substituted anilino-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-ones were synthesized with good yields by the nucleophilic reaction of substituting anilines with 1-(N,N-dimethylamino-)- 4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one. Their structure were confirmed by elemental analysis and 1H NMR. The result of 1H NMR showed that E-configuration were predominant products. The preliminary biological tests indicated that the relative inhibition rate of compound 1n (R=3-OCH3) to Coniothyrium diplodiella and Cladosporium cucumerinum were all 100% at the concentration of 50 μg/mL, and its relative promote to cucumber root is 155.2%.