Synthesis and Biological Activity of Methyl N-Methoxylcarbamates Containing Pyrimidine

In an attempt to find novel compounds with high activity and low toxicity, nine novel methyl N-methoxylcarbamates containing pyrimidine derivatives ( 4a~4i ) were designed and synthesized through substructure link principle. Their structures were confirmed by 1H NMR、IR、LC/MS and elemental analysis. The preliminary biological activity test showed that some compounds possessed fungicidal activities against Gibberella zeae,Pyricularia oryzae and Botrytis cinerea at the concentration of 50 mg/L. The inhibitory ratio of 4b and 4i against G. zeae were 90.9% and 82.6%.The inhibitory ratio of 4c and 4f against P.oryzae were 86.8% and 80.0%,respectively.