Synthesis and Fungicidal Activity of N-(4,6-Disubstitued pyrimidin-2-yl)-benzamides

In search of safer and more effective fungicidal compounds,eight N-(4,6-disubstitued pyrimidin-2-yl)-benzamides were designed and synthesized.Their structures were confirmed by IR,1H NMR,LC/MS and elemental analysis.Preliminary bioassay showed that some of the title compounds showed good fungicidal activity,for example, 4g exhibited 85.1% inhibition rate to Pyricularia oryzae at 25 mg/L and 4f exhibited 92.9% inhibition rate to Gibberella zeae at 25 mg/L.