Studies on Pyridine Derivatives(X):Synthesis and Herbicidal Activity of 2-sec-Butylamino-5-(2-aryloylpyrid-4-yl)-1,3,4-thiodiazoles

2-sec-Butylamino-5-(2-chloropyrid-4-yl)-1,3,4-thiodiazole(BCPT) is a herbicidal leading compound.In order to improve its herbicidal activity and study the relationship between chemical structure and bioactivity,an aryl ether moiety was introduced to the sketch and a new series of compounds were synthesized and the structures were confirmed by 1H NMR and elementary analysis.Preliminary bioassay showed that all the synthesized compounds just showed a poor inhibition rate (0~45%) at 500 mg/L,much weaker than (BCPT) (72%~87%).The result suggested that chloro-atom on 2-position of pyridine ring may be indispensable for herbicidal activity.