Synthesis and Biological Activity of 2-(4-Arylthiazol-2-yl)-3-hydroxyacrylonitrile

In order to find novel 2-(2-thiazolyl)acrylonitrile lead compounds,nine 2-(4-arylthiazol-2-yl)-3-hydroxyacrylonitriles were synthesized by reaction of 2-(4-aryllthiazol-2-yl)acetonitrile and acyl chloride in presence of pyridine or sodium hydride.Their structures were comfirmed by 1H NMR,MS and elemental analysis.The preliminary bioassay indicated that some of the compounds have some insecticidal and fungicidal activity,especially the inhibition rate of compound 5f against Fusarium oxysporium was above 90% at 100 mg/L and the mortality rate of compound 5e against Aphis fabae was about 95% at 250 mg/L.The comparative determining on the toxicity of Aphis fabae indicated that the toxicity of compound 5e was better than compound 6 .