Effects of Two Heterogenous TEII on Abamectin Produced byStreptomyces avermitilis NRRL8165

Two mutations were constructed by the conjugation of two heterogenous (TEII) into S.avermitilis NRRL8165.The effects of TEII on abamectin products were determined by comparing with the wild strain based on the equalized fermentation.The results indicated that the abamectin products increased by 96.52% and 38.06%,respectively ,after the TEII of Tetrocarcin A and Chlorothricin was inserted into S.avermitilis NRRL8165 respectively.It further verified the function of editing and errors-correcting of TEII on polyketide secondary metabolic production.