Mechanism of tobacco mosaic virus by tricyclohexyltin chloride

Inactivation methods were used to study the inhibition effects of tricyclohexyltin chloride against tobacco mosaic virus (TMV).The inhibition effects of tricyclohexyltin chloride against TMV,TMV-RNA and TMV coat-protein (TMV-CP) were studied by electron microscope,agarose gel electrophoresis and ultraviolet spectroscopy,respectively.Electron microscope study indicated that the TMV particles were fractured after treated with 500 μ g/mL tricyclohexyltin chloride for 30 min in vitro (inhibition rate up to 75.77%±0.11%,P<0.01).The experimental results also showed that TMV-RNA degradated and the polymerization of TMV-CP inhibited by treated with tricyclohexyltin chloride.