Synthesis and herbicidal activity of 5-(2-furanyl) cyclohexane-1,3-diones derivatives

In order to explore the structure-activity relationship of triketones,a series of 2-acyl-5-(2-furnayl)-cyclohexane-1,3-diones derivatives were synthesized starting from 2-furaldehyde via acetone aldol condensation and diethyl malonate Michel reaction,then intramolecular cyclization of aldol condensation.The structures of these compounds were confirmed by 1H NMR,13 C NMR and HRMS.The in vitro bioassay results showed that 2-benzoyl-5-(2-furanyl)-cyclohexane-1,3-diones show more low herbicidal activity than natural product AB5046A,and 2-acyl and propionyl derivatives have high herbicidal activity.Compound T3 showed 82.9% inhibition rate at the dosage of 100 μ g/mL against Brassica campestris L.