Bioactivity of phenanthroindolizidine alkaloids and their salt derivatives

Fungicidal and herbicidal activity of a series of phenanthroindolizidine alkaloid and its salt derivatives were determined by mycelial growth method and pot experiment. The results showed that the alkaloid and derivatives have good fungicidal activity, especially (±)-antofine ( 2 ) and (±)-deoxytylophorinine ( 3 ),which showed 70%-100% inhibition rate against Alternaria solani,Cercospora arachidicola,Physalospora piricola and Cladosporium cucumerium at 50 μ g/mL;however,the alkaloid and derivatives showed no herbicidal activity.